The large intestine is about 4. The large intestine differs in physical form from the small intestine in several ways.
The large intestine is much wider, and the longitudinal layers of the muscularis are reduced to three, strap-like structures known as the taeniae coli. The wall of the large intestine is lined with simple columnar epithelium. Instead of having the evaginations of the small intestine villi , the large intestine has invaginations the intestinal glands. While both the small intestine and the large intestine have goblet cells, they are more abundant in the large intestine. The appendix is attached to its inferior surface of the cecum.
It contains the least lymphoid tissue, and it is a part of mucosa-associated lymphoid tissue, which gives it an important role in immunity. Appendicitis is the result of a blockage that traps infectious material in the lumen. The appendix can be removed with no apparent damage or consequence to the patient. On the surface of the large intestine, bands of longitudinal muscle fibers called taeniae coli, each about 0.
There are three bands, starting at the base of the appendix and extending from the cecum to the rectum. Along the sides of the taeniae, tags of peritoneum filled with fat, called epiploic appendages or appendices epiploicae are found. The sacculations, called haustra, are characteristic features of the large intestine, and distinguish it from the small intestine. The large intestine has taeniae coli and invaginations the intestinal glands , unlike the small intestines.
The large intestine, or large bowel, is the last part of the digestive system in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass the useless waste material from the body.
The large intestine consists of the cecum, colon, rectum, and anal canal. It starts in the right iliac region of the pelvis, just at or below the right waist, where it is joined to the bottom end of the small intestine. From here it continues up the abdomen, across the width of the abdominal cavity, and then it turns downward, continuing to its endpoint at the anus.
The large intestine differs in physical form from the small intestine in being much wider. These three bands start at the base of the appendix and extend from the cecum to the rectum. Along the sides of the taeniae are tags of peritoneum filled with fat; these are called epiploic appendages, or appendices epiploicae.
While both the small intestine and the large intestine have goblet cells that secrete mucin to form mucus in water, they are abundant in the large intestine. Sigmoid colon : A photograph of the large bowel sigmoid colon that shows multiple diverticula on either side of the longitudinal muscle bundle Taenia coli.
The crypts and intestinal villi are covered by epithelium that contains two types of cells: goblet cells that secrete mucus and enterocytes that secrete water and electrolytes. The enterocytes in the mucosa contain digestive enzymes that digest specific food while they are being absorbed through the epithelium.
These enzymes include peptidases, sucrase, maltase, lactase and intestinal lipase. This is in contrast to the stomach, where the chief cells secrete pepsinogen. In the intestine, the digestive enzymes are not secreted by the cells of the intestine.
Also, new epithelium is formed here, which is important because the cells at this site are continuously worn away by the passing food. The basal portion of the crypt, further from the intestinal lumen, contains multipotent stem cells. During each mitosis, one of the two daughter cells remains in the crypt as a stem cell, while the other differentiates and migrates up the side of the crypt and eventually into the villus.
Goblet cells are among the cells produced in this fashion. Many genes have been shown to be important for the differentiation of intestinal stem cells. The largest bacteria ecosystem in the human body is in the large intestine, where it plays a variety of important roles. The large intestine houses over species of bacteria that perform a wide variety of functions; it is the largest bacterial ecosystem in the human body.
The large intestine absorbs some of the products formed by the bacteria that inhabit this region. For example, undigested polysaccharides fiber are metabolized to short-chain fatty acids by the bacteria in the large intestine, and then are absorbed by passive diffusion. The bicarbonate that the large intestine secretes helps to neutralize the increased acidity that results from the formation of these fatty acids.
Bacterial flora : Escherichia coli is one of the many species of bacteria present in the human gut. These bacteria also produce large amounts of vitamins, especially vitamin K and biotin a B vitamin , for absorption into the blood.
Although this source of vitamins, in general, provides only a small part of the daily requirement, it makes a significant contribution when dietary vitamin intake is low. An individual who depends just on the absorption of vitamins formed by bacteria in the large intestine may become vitamin deficient if treated with antibiotics that inhibit other species of bacteria, as well as the disease-causing bacteria. Other bacterial products include gas flatus , which is a mixture of nitrogen and carbon dioxide, with small amounts of hydrogen, methane, and hydrogen sulphide.
These are produced as a result of the bacterial fermentation of undigested polysaccharides. The normal flora is also essential for the development of certain tissues, including the cecum and lymphatics. Bacterial flora is also involved in the production of cross-reactive antibodies. These are antibodies produced by the immune system against the normal flora, that are also effective against related pathogens, and prevent infection or invasion.
The most prevalent bacteria are the bacteroides, which have been implicated in the initiation of colitis and colon cancer. Bifidobacteria are also abundant, and are often described as friendly bacteria. A mucus layer protects the large intestine from attacks from colonic commensal bacteria. Some factors that disrupt the microorganism population of the large intestine include antibiotics, stress, and parasites. In the large intestine, a host of microorganisms known as gut flora help digest the remaining food matter and create vitamins.
Digestive processes in large intestine : This image shows the relationship of the colon to the other parts of the digestive system. The large intestine takes about 16 hours to finish up the remaining processes of the digestive system. Food is no longer broken down at this stage of digestion.
The colon absorbs vitamins created by the colonic bacteria—such as vitamin K especially important as the daily ingestion of vitamin K is not normally enough to maintain adequate blood coagulation , vitamin B12, thiamine, and riboflavin. Related questions In what organ is the waste from the digestion process collected for eventual disposal? What organs are affected by diverticulitis? What are the names of the tissue layers of the stomach?
What are dimensions of the small intestine? What are reasons to explain why the small intestine Where does the process of digestion begin? Are nutrients absorbed from the large intestine? How do nutrients, absorbed by the small intestine, travel to the individual cells of the human body? Is the pH of the small intestine lower or higher than that of the stomach? The liver , gallbladder , and pancreas are accessory organs of the digestive system that are closely associated with the small intestine.
The small intestine is divided into the duodenum , jejunum , and ileum. The small intestine follows the general structure of the digestive tract in that the wall has a mucosa with simple columnar epithelium , submucosa , smooth muscle with inner circular and outer longitudinal layers, and serosa. The absorptive surface area of the small intestine is increased by plicae circulares , villi, and microvilli.
Exocrine cells in the mucosa of the small intestine secrete mucus , peptidase, sucrase, maltase, lactase, lipase, and enterokinase. Endocrine cells secrete cholecystokinin and secretin. The most important factor for regulating secretions in the small intestine is the presence of chyme. This is largely a local reflex action in response to chemical and mechanical irritation from the chyme and in response to distention of the intestinal wall.
This is a direct reflex action, thus the greater the amount of chyme, the greater the secretion. The large intestine is larger in diameter than the small intestine.
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